Ethyl isocyanate → N-(1-Boc-piperidin-3-yl-methyl)-N-phenyl-N'-ethylurea

HRID 496660노트

반응식

HRID 496660 반응식
[C:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH2:22]([N:24]=[C:25]=[O:26])[CH3:23]>C(Cl)Cl>[C:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([CH2:14][N:15]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[C:25]([NH:24][CH2:22][CH3:23])=[O:26])[CH2:9]1)([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2]

참가 물질

4

반응물 2

HCID 8022Ethyl isocyanateHCID 12972131N-(1-Boc-piperidin-3-ylmethyl)aniline

생성물 1

HCID 12972132N-(1-Boc-piperidin-3-yl-methyl)-N-phenyl-N'-ethylurea수율 95%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of N-(1-Boc-piperidin-3-ylmethyl)aniline 1 (102 mg, 0.35 mmol) in 1 mL of dry CH2Cl2 was added ethyl isocyanate (95%, 35 μL, 1.2 eq.) at room temperature. After being shaken at room temperature for overnight, the reaction mixture was passed through an aminopropyl NH2 cartridge and washed with CH2Cl2. Removal of the CH2Cl2 afforded N-(1-Boc-piperidin-3-yl-methyl)-N-phenyl-N′-ethylurea (2) (120 mg, 95%). LRMS 285 (M−100)+ 261.

후처리

  1. washwashed with CH2Cl2
  2. customRemoval of the CH2Cl2

출처 및 근거

ORD 기록
ord-45242b6f677f4e619f9e707e4be62ec0
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06946477B2

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