Pyrazole → 3-(1H-pyrazol-1-yl)propanoic acid
반응식
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[C:6]([OH:10])(=[O:9])[CH:7]=[CH2:8]>C(N(CC)CC)C>[N:1]1([CH2:8][CH2:7][C:6]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=[N:2]1참가 물질
4
실험 절차
In a 10 mL round-bottomed flask equipped with a condenser and a stirring bar was placed pyrazole (0.50 g, 7.3 mmol), acrylic acid (0.50 mL, 7.3 mmol) and triethylamine (3 mL). The reaction mixture was refluxed for 6 hours. After removing triethylamine, the viscous oil was dried on high vacuo during 12 hours to yield quantitatively the desired acid (1.0 g) suitable for the next step without further purification.
후처리
- customIn a 10 mL round-bottomed flask equipped with a condenser and a stirring bar
- temperatureThe reaction mixture was refluxed for 6 hours
- customAfter removing triethylamine
- customthe viscous oil was dried on high vacuo during 12 hours
출처 및 근거
- ORD 기록
- ord-722df924973d401887292c8a632727dd
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06946481B1
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