Potassium Carbonate → (R)-3-(2-bromopyridine-3-yloxy)-2-methyl-1-propanol

HRID 496811노트

반응식

HRID 496811 반응식
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C@H:17]([CH3:20])[CH2:18][OH:19]>CC(CC)=O>[Br:1][C:2]1[C:7]([O:8][CH2:16][C@H:17]([CH3:20])[CH2:18][OH:19])=[CH:6][CH:5]=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 230702-Bromo-3-pyridinolHCID 10441885(R)-(-)-3-Bromo-2-methyl-1-propanol

생성물 1

HCID 86595487(R)-3-(2-bromopyridine-3-yloxy)-2-methyl-1-propanol수율 80%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

반응 조건

온도
100 °C

실험 절차

2-bromo-3-pyridinol (230 mg) and potassium carbonate (216 mg) was dissolved in methylethylketone (10 ml) and reacted for 30 minutes. Then, (R)-3-bromo-2-methyl-1-propanol (0.21 ml) was added to the solution and refluxed for 3 hours at 100° C. Potassium carbonate was filtered out and separated by flash chromatography under a silica gel phase (ethyl acetate:normal hexane=1:1). As a result, (R)-3-(2-bromopyridine-3-yloxy)-2-methyl-1-propanol (260 mg, yield: 80%) was obtained.

후처리

  1. customreacted for 30 minutes
  2. filtrationPotassium carbonate was filtered out
  3. customseparated by flash chromatography under a silica gel phase (ethyl acetate:normal hexane=1:1)

출처 및 근거

ORD 기록
ord-5fa2f4940eee4c5b8f3328438231e505
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06946558B2

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