Formaldehyde → trans-4,4,5,5-Tetramethyl-2-oct-1-enyl-1,3,2-dioxaborolane

1-Octyne (2.95 ml, 20 mmol) was added slowly (˜20 min) to a suspension of freshly prepared di(1-isopropyl-3-methylbut-2-enyl)borane, with the reaction temperature being below 5° C. The mixture formed was stirred at 0° C. for 1 hour, slowly quenched with H2O (3 ml) (with some gas evolution occurring) and stirred at RT for 0.5 hour, after which a solution of formaldehyde (1.50 ml, 20 mmol, 37% strength by weight solution in water) was added all at once (exothermic reaction, cooling bath necessary). The reaction mixture was stirred at RT for 1 hour and then admixed with pinacol (2.60 g, 22 mmol). After stirring at RT for 24 hours, the mixture was diluted with H2O (40 ml) and extracted with heptane (40 ml), after which the organic extract was washed with H2O (5×25 ml), dried (Na2SO4) and evaporated under reduced pressure. The residue obtained was carefully distilled under reduced pressure (bulb tube), giving 3.19 g of the product (13.39 mmol, 67% yield) in the form of a colorless liquid, b.p. 70-80° C. (0.15 mm of Hg); IR (film) 2928, 1639, 1363, 1319, 1146 cm−1; 1H-NMR (300 MHz, acetone-d6) 6.55 (dt, 1H, J=18.0, 6.6 Hz), 5.35 (dt, 1H, J=18.0, 1.5 Hz), 2.17-2.09 (m, 2H), 1.50-1.20 (m, 8H), 1.21 (s, 12H), 0.90-0.85 (m, 3H); 13C-NMR (75.4 MHz, acetone-d6) 155.0, 83.6, 36.5, 32.5, 29.7, 29.2, 25.2, 23.3, 14.4;

1. custombeing below 5° C
2. customThe mixture formed
3. customslowly quenched with H2O (3 ml) (with some gas evolution
4. stirringstirred at RT for 0.5 hour
5. customat once (exothermic reaction, cooling bath necessary)
6. stirringThe reaction mixture was stirred at RT for 1 hour
7. stirringAfter stirring at RT for 24 hours
8. extractionextracted with heptane (40 ml)
9. extractionafter which the organic extract
10. washwas washed with H2O (5×25 ml)
11. dry with materialdried (Na2SO4)
12. customevaporated under reduced pressure
13. customThe residue obtained
14. distillationwas carefully distilled under reduced pressure (bulb tube)

ORD 기록

ord-3f02d59b3d9c43e2a4bba9b3ea9c7a0d

출처 데이터셋

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06706925B2