HCID 18188087, 화합물 → t-Butyl 4-amino-3-hydroxy-5-methyl-phenylacetate

HRID 49707노트

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HRID 49707 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH:5]=[C:6]([CH3:11])[C:7]=1[N+:8]([O-])=O>C(O)C.[Pd]>[NH2:8][C:7]1[C:6]([CH3:11])=[CH:5][C:4]([CH2:12][C:13]([O:15][C:16]([CH3:18])([CH3:17])[CH3:19])=[O:14])=[CH:3][C:2]=1[OH:1]

참가 물질

4

반응물 1

HCID 18188087HCID 18188087, 화합물

생성물 1

HCID 18188095t-Butyl 4-amino-3-hydroxy-5-methyl-phenylacetate수율 91.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of t-butyl 3-hydroxy-5-methyl-4-nitrophenylacetate (0.47 g, Reference Example 11) in ethanol (25 mL) was treated with palladium on charcoal (approximately 0.08 g, 10%) and stirred under a hydrogen atmosphere. After 4 hours the mixture was filtered through a pad of celite and the filtrate was evaporated to give the title compound (0.38 g) as a green oil.

후처리

  1. filtrationAfter 4 hours the mixture was filtered through a pad of celite
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-edd0b289e01046f79badea7eddcd0376
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06706738B2

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