Tetrabutylammonium Fluoride → (5S)-5-(Hydroxymethyl)-1-methyl-2-pyrrolidinone
반응식
[N+](CCCC)(CCCC)(CCCC)CCCC.[F-].[Si]([O:26][CH2:27][C@H:28]1[N:32]([CH3:33])[C:31](=[O:34])[CH2:30][CH2:29]1)(C(C)(C)C)(C)C>C1COCC1>[OH:26][CH2:27][C@H:28]1[N:32]([CH3:33])[C:31](=[O:34])[CH2:30][CH2:29]1참가 물질
4
실험 절차
Bu4NF (1 mol THF solution, 17.5 ml, 17.5 mmols) was added to a THF (100 ml) solution of the (5S)-5-[(tert-butyldimethylsilyloxy)methyl]-1-methylpyrrolidin-2-one (3.84 g, 15.8 mmols), and the mixture was stirred for 15 hours at room temperature. The reaction mixture was concentrated under reduced pressure, and then the residue was subjected to silica gel column chromatography (SiO2 150 g, MeOH—CHCl3 1:9 v/v) to obtain (5S)-5-(hydroxymethyl)-1-methylpyrrolidin-2-one as a mixture (2.46 g) with inseparable impurities.
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-b498f257915f4d9c97597204d92e3915
- 출처 데이터셋
- uspto-grants-2005_09
- 특허 번호
- US06949553B2
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