Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Bromo-4'-(methylsulfonyl)acetophenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 4-Methylsulfonylacetophenone | HCID 82529 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 2-Bromo-4'-(methylsulfonyl)acetophenone | HCID 735823 | 78% |
반응 단계
To a solution of 4-(methylsulfonyl)acetophenone (4.85 g, 24.5 mmol) in CHCl3 (70 ml) was added aluminum chloride (1 mg) and bromine (1.1 mL) in CHCl3 (8.5 mL) dropwise. The mixture was stirred overnight, and poured into water. The whole was extracted with ethyl acetate (50 mL×2), the combined organic layer was dried over MgSO4, and concentrated in vacuo. The resulting residue was recrystallized from ethyl acetate/hexane (1/1) to give the subtitle compound (5.28 g, 78% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06949536B2 |
| 출처 데이터셋 | uspto-grants-2005_09 |
| ORD ID | ord-14422ff21bb84ea78959e159be1bdf27 |
| 출처 메모 | uspto-grants-2005_09 |