Water → 4-(2-Furyl)Aniline Hydrochloride

HRID 497184노트

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HRID 497184 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[O:11][CH:12]=[CH:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.O>C(O)C>[O:11]1[CH:12]=[CH:13][CH:14]=[C:10]1[C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 6049692-(4-Nitrophenyl)furan

생성물 1

HCID 41911054-(2-Furyl)Aniline Hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
70 °C

실험 절차

To a suspension of 2-(4-nitrophenyl)furan (0.378 g, 2 mmol, prepared according to the method of Heterocycles, 1990, 31, 1951) in ethanol (20 mL) was heated to 70° C. and added stannous chloride dihydrate (2.26 g, 10 mmol) and the mixture was stirred for 2 hours. The reaction mixture was cooled to room temperature and poured into water (50 mL), the whole was extracted with ethyl acetate (30 mL×2). The organic layer was dried over Na2SO4, filtered through celite and concentrated to give the crude subtitle compound (0.35 g). MS (EI): m/z 159 (M+)

후처리

  1. customprepared
  2. temperatureThe reaction mixture was cooled to room temperature
  3. extractionthe whole was extracted with ethyl acetate (30 mL×2)
  4. dry with materialThe organic layer was dried over Na2SO4
  5. filtrationfiltered through celite and
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f1bb5a00923a44739650c7c3e74e83e8
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949536B2

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