Potassium Carbonate → [4-(1,4-Benzodioxan-5-yl)-1,2,3,6-tetrahydropyrid-1-yl]acetonitrile

HRID 4972

반응식

HRID 4972 반응식
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]#[N:10].Cl.[O:12]1[C:17]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH2:23][CH2:24][NH:25][CH2:26][CH:27]=3)[C:16]=2[O:15][CH2:14][CH2:13]1>CC(C)=O>[O:12]1[C:17]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3[CH2:23][CH2:24][N:25]([CH2:8][C:9]#[N:10])[CH2:26][CH:27]=3)[C:16]=2[O:15][CH2:14][CH2:13]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 190962384-[(1,4-Benzodioxan-5-yl)]-1,2,3,6-tetrahydropyridine hydrochloride

생성물 1

HCID 19105274[4-(1,4-Benzodioxan-5-yl)-1,2,3,6-tetrahydropyrid-1-yl]acetonitrile

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

2.5 g of potassium carbonate and, dropwise, a solution of 1.08 g of bromoacetonitrile in 10 ml of acetone are added to a solution of 1.9 g of the amine hydrochloride obtained in Stage B in 40 ml of acetone.

출처 및 근거

ORD 기록
ord-8836235aef454333bcb8b379cc7831d3
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05242933

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