Bromine → 2-Bromo-1-(2-fluoro-4-hydroxyphenyl)ethanone

HRID 497224노트

반응식

HRID 497224 반응식
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:3]1[CH:4]=[CH:5][C:6]([OH:8])=[CH:7][C:2]=1[F:1])=[O:11]

참가 물질

4

반응물 2

HCID 24408BromineHCID 27249122'-Fluoro-4'-hydroxyacetophenone

생성물 1

HCID 223137872-Bromo-1-(2-fluoro-4-hydroxyphenyl)ethanone수율 62%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a stirred solution of 1-(2-fluoro-4-hydroxyphenyl)-1-ethanone (2.56 g, 16.6 mmol) in dioxane (4 ml) was added a solution of bromine (2.70 g, 16.9 mmol) in dioxane (15 ml) dropwise, and the mixture was stirred for 3 hours. The volatile was evaporated in vacuo, and the residue was used for next reaction without purification. (2.4 g, 62% yield).

후처리

  1. customThe volatile was evaporated in vacuo
  2. customthe residue was used for next reaction without purification

출처 및 근거

ORD 기록
ord-7b122248f85c4440aac2403ef6a46b52
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949536B2

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