Bromine → 2-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one

HRID 497300노트

반응식

HRID 497300 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[OH:8].[Br:12]Br>O1CCOCC1>[Br:12][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1)=[O:11]

참가 물질

4

반응물 2

HCID 24408BromineHCID 27373251-(3-Fluoro-4-hydroxyphenyl)ethan-1-one

생성물 1

HCID 179235302-Bromo-1-(3-fluoro-4-hydroxyphenyl)ethan-1-one수율 99.8%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a stirred solution of 1-(3-fluoro-4-hydroxyphenyl)-1-ethanone (2.0 g, 12.98 mmol) in dioxane (3 ml) was added a solution of bromine (2.09 g, 13.1 mmol) in dioxane (12 ml), and the mixture was stirred for 16 hours. The mixture was concentrated in vacuo to give title compound (3.02 g, 99% yield). The compound was used for next reaction without purification.

후처리

  1. concentrationThe mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-25a4e902a54e4b2e9f9e10a3da35d97c
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949536B2

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