반응식
[ClH:1].Cl.[CH3:3][C:4]1[CH:5]=[CH:6][C:7](OS(C2C=CC=CC=2S(N(C)CC2C=NC=CC=2)(=O)=O)(=O)=O)=[C:8]([CH:18]=1)[O:9][CH2:10][CH2:11][CH2:12][O:13][NH:14][C:15]([NH2:17])=[NH:16].CC1C=CC([O:54][S:55]([C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][C:59]=2[S:64]([N:67]([CH3:75])[CH2:68][C:69]2[CH:70]=[N:71][CH:72]=[CH:73][CH:74]=2)(=[O:66])=[O:65])(=[O:57])=[O:56])=C(C=1)OCCCON.C(C(=CC1C=CC(O)=CC=1)C(O)=O)#N>>[ClH:1].[ClH:1].[CH3:3][C:4]1[CH:5]=[C:6]([O:54][S:55]([C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][C:59]=2[S:64]([N:67]([CH3:75])[CH2:68][C:69]2[CH:70]=[N:71][CH:72]=[CH:73][CH:74]=2)(=[O:65])=[O:66])(=[O:57])=[O:56])[CH:7]=[C:8]([CH:18]=1)[O:9][CH2:10][CH2:11][CH2:12][O:13][NH:14][C:15]([NH2:17])=[NH:16]참가 물질
실험 절차
3-[5-Methyl-3-[(2-(N-methyl-N-(3-pyridylmethyl)aminosulfonyl)phenylsulfonyloxy]phenoxy]propoxyguanidine dihydrochloride: The title compound was prepared in 76% yield from 3-[5-methyl-3-[(2-(N-methyl-N-(3-pyridylmethyl)aminosulfonyl) phenylsulfonyloxy]phenoxy]propoxyamine, as prepared in the preceding step, in a manner analogous to step f of Example 1. 1H-NMR (300 MHz, DMSO-d6) δ 8.78 (t, J=5.2 Hz, 2H), 8.23 (m, 3H), 8.06 (t, J=7.7 Hz, 1H), 7.94 (t, J=7.7 Hz, 1H), 7.88 (t, J=7.9 Hz, 1H), 7.71 (br s, 4H), 6.75 (s, 1H), 6.55 (s, 1H), 6.51 (s, 1H), 4.72 (s, 2H), 3.99 (t, J=6.3 Hz, 2H), 3.90 (t, J=6.4 Hz, 2H), 2.88 (s, 3H), 2.22 (s, 3H), 2.01 (pentet, J=6.4 Hz, 2H). Mass spectrum (MALDI-TOF, α-cyano-4-hydroxycinnamic acid matrix) calcd. for C24H29N5O7S2: 564.2 (M+H), 586.1 (M+Na). Found: 564.1, 586.2.
후처리
- customas prepared in the preceding step, in a manner analogous to step f of Example 1
출처 및 근거
- ORD 기록
- ord-67ab802bade6490783a1670bd7a4a174
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06706765B2
연결된 노트
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