Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | tert-Butoxycarbonyl-L-isoleucine | HCID 2724762 | — |
| 반응물 | 3,3-Difluoroazetidine hydrochloride | HCID 2758247 | — |
| 생성물 | (S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride | HCID 69713143 | — |
반응 단계
(S)-2-amino-1-(3,3-difluoro-azetidin-1-yl)-3-methyl-pentan-1-one hydrochloride was prepared by coupling 3,3-difluoro-azetidine hydrochloride (WO 0047582) with Boc-(L)-isoleucine followed by HCl deprotection as analogously described in Example 1 (mp 195° C. dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710040B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-8454b09149134b8bb6599e0436bd96ab |
| 출처 메모 | uspto-grants-2004_03 |