tert-Butoxycarbonyl-L-isoleucine → (S)-2-amino-1-(4,4-difluoro-piperidin-1-yl)-3-methyl-pentan-1-one hydrochloride

반응식

[ClH:1].[F:2][C:3]1([F:9])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C([NH:17][C@H:18]([C:23](O)=[O:24])[C@H:19]([CH2:21][CH3:22])[CH3:20])(OC(C)(C)C)=O>>[ClH:1].[NH2:17][C@@H:18]([CH:19]([CH3:20])[CH2:21][CH3:22])[C:23]([N:6]1[CH2:7][CH2:8][C:3]([F:9])([F:2])[CH2:4][CH2:5]1)=[O:24]

참가 물질

반응물 2

HCID 2724762tert-Butoxycarbonyl-L-isoleucine

HCID 27583514,4-Difluoropiperidine hydrochloride

생성물 1

HCID 69712100(S)-2-amino-1-(4,4-difluoro-piperidin-1-yl)-3-methyl-pentan-1-one hydrochloride

실험 절차

(S)-2-amino-1-(4,4-difluoro-piperidin-1-yl)-3-methyl-pentan-1-one hydrochloride was prepared from 4,4-difluoro-piperidine hydrochloride and Boc-(L)-isoleucine as described in Example 1 (mp 190-192° C.).

출처 및 근거

ORD 기록: ord-7689ffb0135244b39fb4391353a7ea55
출처 데이터셋: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06710040B1

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