Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N-Dimethylaniline → 7-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N-Dimethylaniline | HCID 949 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | HCID 178508256 | HCID 178508256 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 7-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine | HCID 11221650 | — |
반응 단계
The product from example 1, step (a) (0.89 g), phosphorus oxychloride (12 ml) and N,N-dimethylaniline (1.2 ml) were heated at reflux for 2 hours. The cooled reaction mixture was poured onto ice water and stirred for 2 hours. Chromatography (SiO2, methanol/dichloromethane as eluant) gave the subtitled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06949643B2 |
| 출처 데이터셋 | uspto-grants-2005_09 |
| ORD ID | ord-02e158189ca04e1f92f16acf9bf29cee |
| 출처 메모 | uspto-grants-2005_09 |