Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide → 4-fluoro-N-(piperidin-4-yl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide | HCID 702501 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-fluoro-N-(piperidin-4-yl)benzamide | HCID 4778226 | 97.9% |
반응 단계
A mixture of N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (937 mg) and 10% palladium on carbon (50% wet, 0.2 g) in methanol (20 ml) was stirred under hydrogen atmosphere for 7.5 hours at ambient temperature. The catalyst was removed by glass filter and the solvent was removed under reduced pressure. After rinse with diisopropyl ether, N-(piperidin-4-yl)-4-fluorobenzamide (653 mg) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710043B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-86d50f487be049008b0004230cdd7116 |
| 출처 메모 | uspto-grants-2004_03 |