N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide → 4-fluoro-N-(piperidin-4-yl)benzamide

HRID 49775

반응식

HRID 49775 반응식
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].CO>[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:23])[C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:12][CH2:13]1

참가 물질

4

반응물 1

HCID 702501N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide

생성물 1

HCID 47782264-fluoro-N-(piperidin-4-yl)benzamide수율 97.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (937 mg) and 10% palladium on carbon (50% wet, 0.2 g) in methanol (20 ml) was stirred under hydrogen atmosphere for 7.5 hours at ambient temperature. The catalyst was removed by glass filter and the solvent was removed under reduced pressure. After rinse with diisopropyl ether, N-(piperidin-4-yl)-4-fluorobenzamide (653 mg) was obtained.

후처리

  1. customThe catalyst was removed by glass
  2. filtrationfilter
  3. customthe solvent was removed under reduced pressure
  4. washAfter rinse with diisopropyl ether

출처 및 근거

ORD 기록
ord-86d50f487be049008b0004230cdd7116
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710043B1

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