Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluorophenyl isocyanate → 1-Acetyl-4-(4-fluorophenylcarbamoyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| 반응물 | 1-Acetylpiperazine | HCID 83795 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-Acetyl-4-(4-fluorophenylcarbamoyl)piperazine | HCID 9860094 | 112.6% |
반응 단계
To a stirred solution of 1-acetylpiperazine (0.648 g) in tetrahydrofuran (10 ml) was added 4-fluorophenyl isocyanate (0.574 g) at ambient temperature. After stirring at ambient temperature for 1 hour, the solvent was removed by evaporation under reduced pressure, and the residue was triturated with diisopropyl ether to give 1-acetyl-4-(4-fluorophenylcarbamoyl)piperazine (1.25 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710043B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-f7241cc2bca64ba49d3504aa3103dea6 |
| 출처 메모 | uspto-grants-2004_03 |