Water → 4-(4-Fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine

HRID 49785노트

반응식

HRID 49785 반응식
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1.N1C=CC=CC=1.[F:23][C:24]([F:36])([F:35])[O:25][C:26]1[CH:34]=[CH:33][C:29]([C:30](Cl)=[O:31])=[CH:28][CH:27]=1.O>ClCCl>[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:30](=[O:31])[C:29]3[CH:33]=[CH:34][C:26]([O:25][C:24]([F:23])([F:35])[F:36])=[CH:27][CH:28]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 1421104-(Trifluoromethoxy)benzoyl ChlorideHCID 47782264-fluoro-N-(piperidin-4-yl)benzamide

생성물 1

HCID 98228134-(4-Fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 4-(4-fluorobenzoylamino)piperidine (0.15 g) in dichloromethane (5 ml) were added in turn pyridine (82 μl) and 4-trifluoromethoxybenzoyl chloride (106 μ) at 0° C. The mixture was allowed to warm to ambient temperature and stirred for 4 hours, which was taken up into a mixture of water and dichloromethane. The separated organic layer was washed in turn with hydrochloric acid (1N), aqueous sodium hydrogen carbonate, and brine, and dried over magnesium sulfate. Evaporation of the solvent under reduced pressure gave 4-(4-fluorobenzoylamino)-1-(4-trifluoromethoxybenzoyl)piperidine (205 mg).

후처리

  1. washThe separated organic layer was washed in turn with hydrochloric acid (1N), aqueous sodium hydrogen carbonate, and brine
  2. dry with materialdried over magnesium sulfate
  3. customEvaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-12dc8b3889c647648bf71c64dcb75b6c
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710043B1

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