Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclopropanecarboxylic acid → N-(1-cyclopropylcarbonylpiperidin-4-yl)-4-fluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclopropanecarboxylic acid | HCID 15655 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 4-fluoro-N-(piperidin-4-yl)benzamide | HCID 4778226 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(1-cyclopropylcarbonylpiperidin-4-yl)-4-fluorobenzamide | HCID 9926015 | — |
반응 단계
To a suspension of N-(piperidin-4-yl)-4-fluorobenzamide (556 mg) in dichloromethane (6 ml) were added cyclopropanecarboxylic acid (0.20 ml), 1-hydroxybenzotriazole (338 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (480 mg) at ambient temperature. After stirring for 21 hours, the mixture was diluted with dichloromethane, and washed with water, saturated aqueous sodium hydrogen carbonate, and brine. After drying with magnesium sulfate, the solvents were removed under reduced pressure. After crystallization from diisopropyl ether, N-(1-cyclopropylcarbonylpiperidin-4-yl)-4-fluorobenzamide (627 mg) was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710043B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-172de2d3a4fd4dff8daa387af3ff6796 |
| 출처 메모 | uspto-grants-2004_03 |