Water → 7-Fluoroisatin

HRID 497987

반응식

HRID 497987 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:13])[CH:10]=NO.[OH2:14]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]2[C:3]=1[NH:8][C:9](=[O:13])[C:10]2=[O:14]

참가 물질

4

반응물 2

HCID 962WaterHCID 6710880N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

생성물 1

HCID 5864187-Fluoroisatin수율 46%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
70 °C

실험 절차

A solution of N-(2-fluorophenyl)-2-(hydroxyimino)acetamide (35.0 g, 192 mmol) in sulfuric acid (150 mL) was heated and stirred at 70° C. for 45 minutes. The solution was allowed to cool to room temperature and poured into iced water, and organic matter was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The resulting crystals were collected by filtration to give the title compound (14.6 g, 46% yield).

후처리

  1. temperatureto cool to room temperature
  2. extractionwas extracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated under reduced pressure
  6. filtrationThe resulting crystals were collected by filtration

출처 및 근거

ORD 기록
ord-e546cbf11300420e89834fc0987f4dee
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949648B2

연결된 노트

불러오는 중…