Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Chloromethyl)pyridine → 2-[[3-Methyl-1-(3-pyridinylmethyl)-1H-pyrazol-5-yl]amino]benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Chloromethyl)pyridine | HCID 18358 | — |
| 반응물 | Pyridin-3-ylmethyl-hydrazine | HCID 12232495 | — |
| 반응물 | 2-(2-Oxo-propyl)-benzo[D][1,3]oxazin-4-one | HCID 15938097 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-[[3-Methyl-1-(3-pyridinylmethyl)-1H-pyrazol-5-yl]amino]benzoic acid | HCID 22320205 | 67% |
반응 단계
A solution in ethanol (50 mL) of 2-(2-oxopropyl)-4H-3,1-benzoxazin-4-one (11.2 g, 55.1 mmol) and 3-hydrazinomethylpyridine (7.44 g, 60.4 mmol) which was prepared from 3-chloromethylpyridine following the method described in Reference Example 2-2, was heated under reflux for 1 hour. The solution was cooled to room temperature, and the resulting crude crystals were collected by filtration. The crystals were washed with ethanol and air dried to give the title compound (11.3 g, 67% yield). mp: 180-183° C. (recrystallized from ethanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06949648B2 |
| 출처 데이터셋 | uspto-grants-2005_09 |
| ORD ID | ord-cf44457fb6344e3fba6132667320dab9 |
| 출처 메모 | uspto-grants-2005_09 |