Bromoacetic Acid → HCID 22320730, 화합물

반응식

[Br:1][CH2:2][C:3]([OH:5])=O.[CH2:6]([CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N=C=NC(C)C)(C)C>>[CH2:6]([CH:13]1[CH2:18][CH2:17][N:16]([C:3](=[O:5])[CH2:2][Br:1])[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

반응물 3

HCID 6227Bromoacetic Acid

HCID 12734Diisopropylcarbodiimide

HCID 317384-Benzylpiperidine

생성물 1

HCID 22320730HCID 22320730, 화합물

실험 절차

Prepared as stated above for compound (22) from bromo acetic acid (935mg, 6.78 mmol) and 4-benzyl piperdine (1.02 g, 5.82 mmol) and diisopropylcarbodiimide (856 mg, 6.78 mmol) to afford compound 23, 1.53 g, (89%), (MH+) m/z 297.88.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-251dffb3298f4890b395670388d8d31c
출처 데이터셋: uspto-grants-2005_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06949655B2

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