Methyl 3-(3-pyridinyl)benzoate → 3-Oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester

HRID 498229노트

반응식

HRID 498229 반응식
CO[C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH:5]=1.[C:17]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])(=[O:19])[CH3:18].[Li]>>[C:21]([O:20][C:17](=[O:19])[CH2:18][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH:5]=1)([CH3:24])([CH3:23])[CH3:22]

참가 물질

3

반응물 2

HCID 4133188Methyl 3-(3-pyridinyl)benzoateHCID 86586795Lithium Tert-butyl Acetate

생성물 1

HCID 112664733-Oxo-3-(3-pyridin-3-yl-phenyl)-propionic acid tert-butyl ester

실험 절차

The title compound was prepared from 3-pyridin-3-yl-benzoic acid methyl ester [CAS-No. 79601-27-7] (1.00 g, 4.69 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as an orange oil (673 mg).

출처 및 근거

ORD 기록
ord-587a230e430241afb4926e8958425456
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949542B2

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