Nitric Acid → 4-Fluoro-3-nitrophenylacetic acid

HRID 49824노트

반응식

HRID 49824 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:6][C:7]=1[N+:12]([O-:14])=[O:13]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 98372-(4-Fluorophenyl)acetic acid

생성물 1

HCID 111272614-Fluoro-3-nitrophenylacetic acid수율 70.5%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
0 °C

실험 절차

A suspension of 4-fluorophenylacetic acid (10.0 g, 64.9 mmol) in concentrated sulfuric acid (100 ml) was cooled to 0° C. Concentrated nitric acid (4.5 ml, 65 mmol) was added drop-wise, keeping the temperature at 0-5° C. At the end of the addition the mixture was poured into ice-water (400 ml). The precipitate was filtered off, washed thoroughly with water and dried with suction to yield 1i (9.11 g, 70%).

후처리

  1. customat 0-5° C
  2. additionAt the end of the addition the mixture
  3. filtrationThe precipitate was filtered off
  4. washwashed thoroughly with water
  5. customdried with suction

출처 및 근거

ORD 기록
ord-ad39031bca424b2097b7b12bee955401
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710044B2

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