3-(6-Chloropyrimidin-4-yl)benzoic acid → HCID 69486856, 화합물

HRID 498250노트

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HRID 498250 반응식
CO[C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[C:14]([NH:16][CH2:17][CH2:18][O:19][CH3:20])[N:13]=[CH:12][N:11]=2)[CH:5]=1.ClC1N=CN=C(C2C=[C:31](C=CC=2)[C:32]([OH:34])=[O:33])C=1>COCCN>[C:4]([O:34][C:32](=[O:33])[CH2:31][C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[C:14]([NH:16][CH2:17][CH2:18][O:19][CH3:20])[N:13]=[CH:12][N:11]=2)[CH:5]=1)=[O:21])([CH3:9])([CH3:5])[CH3:3]

참가 물질

4

반응물 2

HCID 223175383-(6-Chloropyrimidin-4-yl)benzoic acidHCID 694899033-[6-(2-Methoxy-ethylamino)-pyrimidin-4-yl]-benzoic acid methyl ester

생성물 1

HCID 69486856HCID 69486856, 화합물

시약·촉매·용매 1

HCID 80182-Methoxyethylamine용매

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온도
50 °C

실험 절차

The title compound was prepared from 3-[6-(2-methoxy-ethylamino)-pyrimidin-4-yl]-benzoic acid methyl ester [prepared by the following procedure: 3-(6-Chloro-pyrimidin-4-yl)-benzoic acid (1.0 g, 4.3 mmol) was heated in 2-methoxy-ethylamine (5 ml) to 80° C. for 1 h. The mixture was evaporated in vacuum and the residual oil was stirred in 1N HCl-MeOH (25 mL) for 18 h at 50° C. The crude product was purified by chromatography (silica gel, AcOEt-hexane 1:1) to give the methyl ester as light yellow solid (0.67 g).] (0.66 g, 2.3 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a light yellow oil (0.93 g, not pure).

후처리

  1. customprepared by the following procedure
  2. customThe mixture was evaporated in vacuum
  3. customThe crude product was purified by chromatography (silica gel, AcOEt-hexane 1:1)

출처 및 근거

ORD 기록
ord-c12ea2c5349f49d991bf7a2a6670ae5b
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949542B2

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