Triethylamine → ethyl 3-(N-(4-(3-furanyl)-2-nitrophenyl))aminobenzoate

HRID 49829

반응식

HRID 49829 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[CH:11][O:10][CH:9]=2)=[CH:4][C:3]=1[N+:13]([O-:15])=[O:14].[NH2:16][C:17]1[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=1)[C:20]([O:22][CH2:23][CH3:24])=[O:21].C(N(CC)CC)C>CN1C(=O)CCC1>[O:10]1[CH:11]=[CH:12][C:8]([C:5]2[CH:6]=[CH:7][C:2]([NH:16][C:17]3[CH:18]=[C:19]([CH:25]=[CH:26][CH:27]=3)[C:20]([O:22][CH2:23][CH3:24])=[O:21])=[C:3]([N+:13]([O-:15])=[O:14])[CH:4]=2)=[CH:9]1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 11400Ethyl 3-aminobenzoateHCID 227418573-(4-Fluoro-3-nitrophenyl)furan

생성물 1

HCID 22741896ethyl 3-(N-(4-(3-furanyl)-2-nitrophenyl))aminobenzoate수율 34%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
110 °C

실험 절차

5-(3-furanyl)-1-(3-(ethoxycarbonyl)phenyl)benzimidazole(6c1) To a solution of 1d (2.07 g, 10 mmol) in NMP (2 ml) was added ethyl 3-aminobenzoate (1.82 g, 11 mmol) and triethylamine and the mixture was heated to 110° C. in a nitrogen atmosphere overnight. The mixture was diluted with ice-water and extracted with ethyl acetate. The concentrated extract was purified by column-chromatography on silica gel using a mixture of petroleum ether and ethyl acetate (9:1 v/v) to yield ethyl 3-(N-(4-(3-furanyl)-2-nitrophenyl))aminobenzoate (1.18 g, 34%). This ester was hydrogenated in ethanol at ambient pressure using Pd (5% on activated carbon) as the catalyst. The resulting diamine (1.07 g) was treated with triethyl orthoformate (1.11 ml, 6.64 mmol) and a catalytic amount of pTSA in refluxing THF (10 ml). Column-chromatographic work-up of the concentrated reaction mixture using ethyl acetate as the eluent afforded 6c1 (0.66 g, 56%). M.p. 87-89° C.

후처리

  1. extractionextracted with ethyl acetate
  2. extractionThe concentrated extract
  3. customwas purified by column-chromatography on silica gel using
  4. additiona mixture of petroleum ether and ethyl acetate (9:1 v/v)

출처 및 근거

ORD 기록
ord-13779fb58d0e4ad28eb9136a2bb9659f
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710044B2

연결된 노트

불러오는 중…