Water → 4-(Morpholin-4-yl)benzoic acid

HRID 49831

반응식

HRID 49831 반응식
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#N)=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O1CCOCC1.[OH-:21].[K+].[OH2:23]>>[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]([OH:23])=[O:21])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

5

반응물 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 312751,4-DioxaneHCID 3948084-Morpholinobenzonitrile

생성물 1

HCID 3452784-(Morpholin-4-yl)benzoic acid수율 99%

실험 절차

A solution of 4-(4-morpholinyl)benzonitrile (930 mg, 5.00 mmol) in 1:1 dioxane:water (20 mL) was treated with potassium hydroxide (1.12 g, 20 mmol). The mixture was heated at reflux for 96 h, concentrated, and the residue was dissolved in water. Upon acidification (pH ˜2-3), a white precipitate resulted which was collected by filtration yielding 1.21 g (99%) of the title compound.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 96 h
  3. concentrationconcentrated
  4. dissolutionthe residue was dissolved in water
  5. customUpon acidification (pH ˜2-3), a white precipitate resulted which
  6. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-7ad0d7d1880144fa87a13458aa991f81
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710057B2

연결된 노트

불러오는 중…