Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → H-Gly-Leu-Ala-OBzl HCl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Trifluoroacetate | HCID 84468 | — |
| 반응물 | H-Leu-Ala-OBzl | HCID 16742166 | — |
| 반응물 | Boc-Gly-Leu-Ala-OBzl | HCID 131717744 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | H-Gly-Leu-Ala-OBzl HCl | HCID 131718105 | — |
반응 단계
Boc-Gly-Leu-Ala-OBzl was prepared by coupling Boc-Gly-OH (5.70 g, 32.6 mmoles) to H-Leu-Ala-OBzl using the mixed anhydride procedure described in Example 2. The product (13.8 g) was obtained as an amorphous solid. Boc-Gly-Leu-Ala-OBzl was deblocked with trifluoroacetic acid by the procedure described for the preparation of H-Leu-Ala-OBzl except that the trifluoroacetate salt was soluble in ether. The preparation was dissolved in ethyl acetate and treated with anhydrous hydrogen chloride. The resulting product was precipitated by the addition of ether to yield 7.7 g of H-Gly-Leu-Ala-OBzl HCl in a first crop.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05242904 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-1e9e6ea312024abbb5827b12a87dd34a |
| 출처 메모 | uspto-grants-1993_09 |