Chloride → 4-(3-{2-[(Methyl-propyl-amino)-methyl]-pyridin-4-yl}-phenyl)-7-(2,2,2-trifluoro-ethoxy)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 498838노트

반응식

HRID 498838 반응식
O[CH2:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:10]=[C:11]([C:15]3[CH2:21][C:20](=[O:22])[NH:19][C:18]4[CH:23]=[C:24]([C:33]([F:36])([F:35])[F:34])[C:25]([O:27][CH2:28][C:29]([F:32])([F:31])[F:30])=[CH:26][C:17]=4[N:16]=3)[CH:12]=[CH:13][CH:14]=2)[CH:6]=[CH:5][N:4]=1.S(Cl)(Cl)=O.[Cl-].[CH3:42][NH:43][CH2:44][CH2:45][CH3:46]>C(Cl)Cl.CN(C=O)C>[CH3:42][N:43]([CH2:2][C:3]1[CH:8]=[C:7]([C:9]2[CH:10]=[C:11]([C:15]3[CH2:21][C:20](=[O:22])[NH:19][C:18]4[CH:23]=[C:24]([C:33]([F:36])([F:34])[F:35])[C:25]([O:27][CH2:28][C:29]([F:30])([F:31])[F:32])=[CH:26][C:17]=4[N:16]=3)[CH:12]=[CH:13][CH:14]=2)[CH:6]=[CH:5][N:4]=1)[CH2:44][CH2:45][CH3:46]

참가 물질

7

반응물 4

HCID 312ChlorideHCID 12315N-MethylpropylamineHCID 24386Thionyl ChlorideHCID 22317746HCID 22317746, 화합물

생성물 1

HCID 223177634-(3-{2-[(Methyl-propyl-amino)-methyl]-pyridin-4-yl}-phenyl)-7-(2,2,2-trifluoro-ethoxy)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared from 4-[3-(2-hydroxymethyl-pyridin-4-yl)-phenyl]-7-(2,2,2-trifluoro-ethoxy)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one (Example 286) (255 mg, 0.50 mmol) by reaction with thionylchloride in CH2Cl2 and subsequent treatment of the corresponding crude chloride with methyl-propyl-amine in DMF according to the general procedure of example 288. Obtained as an off-white solid (207 mg, 73%).

출처 및 근거

ORD 기록
ord-b2e247e552fc4a10913f03ccec631ed6
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949542B2

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