Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(RS)-N-benzyl-N-methyl-2-phenylglycinamide → (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (RS)-N-benzyl-N-methyl-2-phenylglycinamide | HCID 22262712 | — |
| 반응물 | Ditoluoyl-l-tartaric acid | HCID 129746773 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate | HCID 131724412 | — |
반응 단계
In a preferred embodiment, (RS)-N-benzyl-N-methyl-2-phenylglycinamide is treated with di(o-toluoyl)-L-tartaric acid in methanol at 20° C. The precipitated salt is filtered and washed with methanol, then dried providing (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate with 92.7% d.e. (chiral HPLC). This material is reslurried in hot methanol, filtered, washed and dried to providing (S)-N-benzyl-N-methyl-2-phenylglycinamide di(o-toluoyl)-L-tartrate with 99% d.e. (37% overall yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06949572B2 |
| 출처 데이터셋 | uspto-grants-2005_09 |
| ORD ID | ord-2feec55e2be34430a59bf887e2c68f1c |
| 출처 메모 | uspto-grants-2005_09 |