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Potassium Carbonate → [2-Chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)phenyl] 2,2,2-trifluoroethyl sulfide

HRID 498945
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HRID 498945 반응식
[S:1]([C:19]1C=C(C2N(C(F)(F)F)N=NC=2)C(F)=CC=1Cl)[C:2]1[CH:7]=[C:6]([C:8]2[N:9]([C:13]([F:16])([F:15])[F:14])[N:10]=[N:11][CH:12]=2)[C:5]([F:17])=[CH:4][C:3]=1[Cl:18].C(S([O-])=O)O.[Na+].C(=O)([O-])[O-].[K+].[K+].[F:48][C:49]([F:53])([F:52])CI>>[F:48][C:49]([F:53])([F:52])[CH2:19][S:1][C:2]1[CH:7]=[C:6]([C:8]2[N:9]([C:13]([F:15])([F:16])[F:14])[N:10]=[N:11][CH:12]=2)[C:5]([F:17])=[CH:4][C:3]=1[Cl:18]
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참가 물질

5

반응물 4

HCID 11430Potassium CarbonateHCID 677091,1,1-Trifluoro-2-iodoethaneHCID 221709141,1'-Thiodi-[2-chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)benzene]HCID 23689980Sodium Formaldehyde Sulfoxylate

생성물 1

HCID 86587601[2-Chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)phenyl] 2,2,2-trifluoroethyl sulfide수율 96.6%

실험 절차

1.8 g (3.0 mmol) of 1,1′-thiodi-[2-chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)benzene], 2.0 g (13.0 mmol) of Rongalite, 2.0 g (14.5 mmol) of potassium carbonate and 3.2 g (17.6 mmol) of 2,2,2-trifluoroethyl iodide were reacted in the same way as in Example 2 (3) and afforded 1.1 g of [2-chloro-4-fluoro-5-(3-trifluoromethyltriazolyl)phenyl] 2,2,2-trifluoroethyl sulfide (yield 47.8%) as white crystals (m.p. 56-58° C.).

출처 및 근거

ORD 기록
ord-3cf6360da6e04aa9b3cf48f8372b038e
출처 데이터셋
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07767626B2

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