참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Acetylpyridine | HCID 14286 | — |
| 반응물 | Ethyl oxoacetate | HCID 70211 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2-Hydroxy-4-oxo-4-pyridin-2-ylbutyric acid ethyl ester | HCID 67523420 | 44% |
반응 단계
A mixture of ethyl glyoxalate (3.060 g, 30.000 mmol) (6.2 mL of a 50% solution in toluene) and 2-acetylpyridine (3.630 g, 30.000 mmol) was heated in an oil bath at 135° C. for 16 hours. The crude residue after removal of toluene was purified by column chromatography. The pure 2-hydroxy-4-oxo-4-pyridin-2-ylbutyric acid ethyl ester was isolated in 44% yield (2.910 g, 13.000 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07767677B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_08 |
|---|
| ORD ID | ord-cb01fbafd5a64462b5daf05bb07ec02c |
|---|
| 출처 메모 | uspto-grants-2010_08 |
|---|
