Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 49920생성일: 2026년 10월 25일
Triethylamine → Methyl 2-Acetamido-3-[2-(2-(t-butoxycarbonylamino)ethoxy)-4-cyanophenyl]acrylate
https://huagongshe.com/reaction/49920
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Tri-o-tolylphosphine | HCID 80271 | — |
| 반응물 | Methyl 2-acetamidoacrylate | HCID 98644 | — |
| 반응물 | t-Butyl [2-(5-cyano-2-iodophenoxy)ethyl]carbamate | HCID 11111864 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 2-Acetamido-3-[2-(2-(t-butoxycarbonylamino)ethoxy)-4-cyanophenyl]acrylate | HCID 68833044 | — |
반응 단계
18.0 g (46.4 mmol) of 3-[2-(t-butoxycarbonylamino)ethoxy]-4-iodobenzonitrile was dissolved in 200 ml of dimethylformamide (DMF). 13.3 g (92.8 mmol) of methyl 2-acetamidoacrylate, 2.82 g (9.28 mmol) of tris(2-methylphenyl)phosphine, 1.04 g (4.64 mmol) of palladium (II) acetate and 12.9 ml (92.8 mmol) of triethylamine were added to the obtained solution, and they were stirred at 115° C. for 4 hours. The solvent was evaporated to obtain the crude product, which was purified by the silica gel column chromatography to obtain the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06710056B2 |
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| 출처 데이터셋 | uspto-grants-2004_03 |
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| ORD ID | ord-046281170f08469dba7a019a60a28e30 |
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| 출처 메모 | uspto-grants-2004_03 |
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