6-Chloropyridine-2-carbonitrile → 6-(Methylthio)picolinonitrile

HRID 499290노트

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HRID 499290 반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[CH3:10][S-:11].[Na+]>O1CCCC1>[C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([S:11][CH3:10])[N:3]=1)#[N:9]

참가 물질

4

반응물 2

HCID 1184246-Chloropyridine-2-carbonitrileHCID 4378561Sodium methanethiolate

생성물 1

HCID 229394456-(Methylthio)picolinonitrile수율 101.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
90 °C

실험 절차

A mixture of 2-chloro-6-cyanopyridine (0.70 g, 5.0 mmol), sodium thiomethoxide (0.39 g, 5.5 mmol) and tetrahydrofuran (50 ml) was stirred at 90° C. for 18 hrs. The reaction mixture was concentrated under reduced pressure, combined with water and extracted with ethyl acetate. The extract was washed with saturated brine and dried, and the solvent was evaporated under reduced pressure to give the titled compound as an oil (0.76 g, 98%).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with saturated brine
  4. customdried
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ceb8354aad6f4c52b1aca7df984d5ca5
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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