Triethylamine → HCID 68459271, 화합물

HRID 499294노트

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HRID 499294 반응식
[C:1]([O:10]C)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[SH:4].C(O[C:16]1[CH:17]=[CH:18][C:19]([C:22]#N)=[N:20][CH:21]=1)(=O)C.[C:24]([O:27]C1C(C#N)=NC=CC=1)(=[O:26])[CH3:25].[CH2:36]([N:38](CC)CC)C>C1(C)C=CC=CC=1>[C:24]([O:27][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([C:36]2[S:4][C:3]3[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=3[C:1](=[O:10])[N:38]=2)=[CH:21][N:20]=1)(=[O:26])[CH3:25]

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 21009Benzoic acid, 2-mercapto-, methyl esterHCID 22939311HCID 22939311, 화합물HCID 229393796-Cyanopyridin-3-yl acetate

생성물 1

HCID 68459271HCID 68459271, 화합물수율 29%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A mixture of methyl thiosalicylate (0.58 g, 3.43 mmol), a mixture of 5-acetoxy-2-cyanopyridine and 3-acetoxy-2-cyanopyridine (0.60 g, 3.43 mmol), triethylamine (0.72 ml, 5.15 mmol) and toluene (100 ml) was refluxed for 48 hrs as described in Example 1. The solvent was concentrated under reduced pressure. The residue was recrystallized from ethanol to give the titled compound (0.30 g, 29%) as crystals.

후처리

  1. temperaturewas refluxed for 48 hrs
  2. concentrationThe solvent was concentrated under reduced pressure
  3. customThe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-ad03d1d635a24a25863678d24c54012e
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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