Water → 2-(Morpholin-4-yl)pyridine-4-carbonitrile

HRID 499320노트

반응식

HRID 499320 반응식
Cl[C:2]1[CH:7]=[C:6]([C:8]#[N:9])[CH:5]=[CH:4][N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1.O>CN1CCCC1=O>[N:10]1([C:2]2[CH:7]=[C:6]([CH:5]=[CH:4][N:3]=2)[C:8]#[N:9])[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

참가 물질

5

반응물 3

HCID 962WaterHCID 8083MorpholineHCID 5686382-Chloro-4-cyanopyridine

생성물 1

HCID 146408562-(Morpholin-4-yl)pyridine-4-carbonitrile수율 71.1%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
100 °C

실험 절차

2-Chloro-4-cyanopyridine (0.40 g, 2.9 mmol) was dissolved in N-methylpyrrolidone (2.0 ml), and morpholine (0.7 ml, 8.0 mmol) was added thereto. The reaction mixture was stirred at 100° C. for 2.5 hrs and combined with water to give precipitates, which were collected by filtration and dried to give the titled compound (0.39 g, 70%).

후처리

  1. customto give
  2. customprecipitates
  3. filtrationwhich were collected by filtration
  4. customdried

출처 및 근거

ORD 기록
ord-b0bc8802bfae4dfbac604d075b19414e
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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