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Dimethyl Sulfone → HCID 178499878, 화합물

HRID 49936
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HRID 49936 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]([NH:11][C:12](=[CH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][C:19]=1[O:26][CH2:27][C@H:28]([NH:41][C:42](=[O:56])[C:43]1[CH:48]=[CH:47][CH:46]=[C:45]([C:49]2[CH:54]=[CH:53][C:52]([NH2:55])=[CH:51][CH:50]=2)[CH:44]=1)[CH2:29][CH2:30][C:31]([O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:32])[C:13]([O:15][CH3:16])=[O:14])(=[O:10])[CH3:9].Cl.Cl[C:59]([NH2:61])=[NH:60].CS(C)(=O)=O>O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]([NH:11][C:12](=[CH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[CH:20][C:19]=1[O:26][CH2:27][C@H:28]([NH:41][C:42](=[O:56])[C:43]1[CH:48]=[CH:47][CH:46]=[C:45]([C:49]2[CH:54]=[CH:53][C:52]([NH:55][C:59]([NH2:61])=[NH:60])=[CH:51][CH:50]=2)[CH:44]=1)[CH2:29][CH2:30][C:31]([O:33][CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)=[O:32])[C:13]([O:15][CH3:16])=[O:14])(=[O:10])[CH3:9]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6213Dimethyl SulfoneHCID 3084509Chloroformamidinium chlorideHCID 69142761methyl 2-Acetamido-3-[2-[(2R)-2-[[3-(4-aminophenyl)benzoyl]amino]-4-benzyloxycarbonylbutoxy]-4-cyanophenyl]acrylate Trifluoroacetate

생성물 1

HCID 178499878HCID 178499878, 화합물

시약·촉매·용매 1

HCID 962Water용매

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온도
120 °C

실험 절차

A mixture of 340 mg (0.52 mmol) of methyl 2-acetamido-3-[2-[(2R)-2-[[3-(4-aminophenyl)benzoyl]amino]-4-benzyloxycarbonylbutoxy]-4-cyanophenyl]acrylate trifluoroacetate, 430 mg (3.74 mmol) of chloroformamidine hydrochloride and 2.0 g of dimethyl sulfone was stirred at 120° C. for 2 hours. Water was added to the reaction mixture. After washing with ethyl acetate, the aqueous layer was freeze-dried and purified by the reversed phase HPLC in the same manner as that in step 5 in Example 1 to obtain the title compound.

후처리

  1. washAfter washing with ethyl acetate
  2. customthe aqueous layer was freeze-dried
  3. custompurified by the reversed phase HPLC in the same manner as that in step 5 in Example 1

출처 및 근거

ORD 기록
ord-08fbdee52c4a49f6a3a13adebffe294a
출처 데이터셋
uspto-grants-2004_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06710056B2

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