Toluene → Methyl 3-phenylbenzoate

HRID 49939

반응식

HRID 49939 반응식
Br[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:12]1(B(O)O)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[Na+].[Na+].C1(C)C=CC=CC=1>O.C(O)C>[C:12]1([C:2]2[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=2)[C:5]([O:7][CH3:8])=[O:6])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

7

반응물 4

HCID 1140TolueneHCID 10340Sodium CarbonateHCID 12070Methyl 3-bromobenzoateHCID 66827Phenylboronic Acid

생성물 1

HCID 9855857Methyl 3-phenylbenzoate

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

1.00 g (4.65 mmol) of methyl 3-bromobenzoate, 0.60 g (4.88 mmol) of phenylboronic acid, 161 mg (3 molar %) of tetrakistriphenylphosphine palladium and 2.0 g (18.6 mmol) of sodium carbonate were heated under reflux in 24 ml of a solvent mixture of toluene, ethanol and water (2/1/1) for 2 hours. The mixture was filtered through Celite, then after-treated by an ordinary method and purified by the silica gel column chromatography to obtain the title compound.

후처리

  1. filtrationThe mixture was filtered through Celite
  2. additionafter-treated by an ordinary method
  3. custompurified by the silica gel column chromatography

출처 및 근거

ORD 기록
ord-3f42c7fe26a74fb38fbf23ff04995515
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710056B2

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