Tetrahydrofuran → 6-(Methylthio)nicotinonitrile

HRID 499418노트

반응식

HRID 499418 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][N:3]=1.[CH3:10][S-:11].[Na+].C1COCC1.C(OCC)(=O)C>O>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([S:11][CH3:10])=[N:3][CH:4]=1)#[N:9]

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 4378561Sodium methanethiolateHCID 51520946-Chloro-3-pyridinecarbonitrile

생성물 1

HCID 229395276-(Methylthio)nicotinonitrile수율 100%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-Chloro-5-cyanopyridine (2.10 g, 15.1 mmol) and sodium thiomethoxide (1.16 g, 16.5 mmol) were added to THF (30 ml). The reaction mixture was refluxed for 9 hrs and combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (2.26 g, 100%) as pale yellow crystals.

후처리

  1. temperatureThe reaction mixture was refluxed for 9 hrs
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-87a4d9ad0796450d925b4650bea98971
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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