tert-Butyl 3-[6-(7-chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate → 3-[6-(7-Chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid

HRID 499427노트

반응식

HRID 499427 반응식
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[N:15]=[C:14]([CH2:16][CH2:17][C:18]([O:20]C(C)(C)C)=[O:19])[CH:13]=[CH:12][CH:11]=3)[S:9][C:4]=2[CH:3]=1>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]2[C:6](=[O:25])[N:7]=[C:8]([C:10]3[N:15]=[C:14]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH:13]=[CH:12][CH:11]=3)[S:9][C:4]=2[CH:3]=1

참가 물질

3

반응물 1

HCID 22939302tert-Butyl 3-[6-(7-chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate

생성물 1

HCID 597501393-[6-(7-Chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid수율 96%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

반응 조건

온도
0 °C

실험 절차

tert-Butyl 3-[6-(7-chloro-4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propanoate (0.60 g, 1.5 mmol) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at 0° C. for 2 hrs. The solvent was evaporated and the residue was crystallized from diisopropyl ether to give the titled compound (0.49 g, 96%) as white crystals.

후처리

  1. customThe solvent was evaporated
  2. customthe residue was crystallized from diisopropyl ether

출처 및 근거

ORD 기록
ord-8ef0250486a24813a30f62d64ef8eb7b
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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