m-Chloroperbenzoic acid → HCID 86628983, 화합물

HRID 499483노트

반응식

HRID 499483 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:3][CH:2]=1.ClC1C=CC=C(C(OO)=[O:25])C=1>C(OCC)(=O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][NH+:9]([O-:25])[C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 12010540Tert-butyl N-[2-(pyridin-4-YL)ethyl]carbamate

생성물 1

HCID 86628983HCID 86628983, 화합물수율 100.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

tert-Butyl 2-(4-pyridyl)ethylcarbamate (6.9 g, 31 mmol) and 3-chloroperbenzoic acid (77%, 9.1 g, 40 mmol) were dissolved in ethyl acetate (100 ml), and the mixture was stirred at room temperature for 3 hrs. The solvent was evaporated, and the residue was subjected to a silica gel column chromatography. The fractions eluted with methanol-ethyl acetate (1:3, v/v) were collected and concentrated to give the titled compound (7.4 g, 99%).

후처리

  1. customThe solvent was evaporated
  2. washThe fractions eluted with methanol-ethyl acetate (1:3
  3. customv/v) were collected
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a1ba03e748824321b43ba591b4b693a6
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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