Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Fluoro-5-(trifluoromethyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 4-Fluoro-3-nitrobenzotrifluoride | HCID 67778 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 촉매 | Iron | HCID 23925 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Fluoro-5-(trifluoromethyl)aniline | HCID 136349 | 82% |
반응 단계
Twenty grams of 3-nitro-4-fluorobenzotrifluoride was dissolved in 50 ml of methanol. An iron powder (16 g) was added and concentrated hydrochloric acid was added dropwise with stirring. The reaction mixture was stirred overnight, followed by addition of sodium bicarbonate for neutralization. Then diethyl ether was added, and the insolubles were filtered off with cerite. The ether phase was separated, dried and concentrated under reduced pressure, giving 14 g of the contemplated product (yield 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06710062B1 |
| 출처 데이터셋 | uspto-grants-2004_03 |
| ORD ID | ord-67f0e5b6c7a5411682cf7addfc7c992c |
| 출처 메모 | uspto-grants-2004_03 |