Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 2-Cyano-6-methylthiopyrazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 6-Chloropyrazine-2-carbonitrile | HCID 81303 | — |
| 반응물 | Sodium methanethiolate | HCID 4378561 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Cyano-6-methylthiopyrazine | HCID 22939281 | 83% |
반응 단계
A mixture of 2-chloro-6-cyanopyrazine (1.40 g, 10.0 mmol), sodium thiomethoxide (0.78 g, 11.0 mmol) and THF (100 ml) was refluxed for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated to give the titled compound (1.25 g, 83%) as pale yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07767665B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-10c916b4118a4d4fb5af290e415fd27f |
| 출처 메모 | uspto-grants-2010_08 |