Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine → 6-(Dimethylamino)pyrazine-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 6-Chloropyrazine-2-carbonitrile | HCID 81303 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 6-(Dimethylamino)pyrazine-2-carbonitrile | HCID 23273459 | 55% |
반응 단계
2-Chloro-6-cyanopyrazine (0.85 g, 6.09 mmol) and 1.67 N dimethylamine in acetonitrile (4.00 ml, 6.70 mmol) were added to THF (100 ml), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (0.50 g, 55%) as pale yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07767665B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-aa45f43810d74b31af6b3328805d96d4 |
| 출처 메모 | uspto-grants-2010_08 |