Dimethylamine → 6-(Dimethylamino)pyrazine-2-carbonitrile

HRID 499556

반응식

HRID 499556 반응식
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[CH3:10][NH:11][CH3:12].C(#N)C.C1COCC1>O.C(OCC)(=O)C>[C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:11]([CH3:12])[CH3:10])[N:3]=1)#[N:9]

참가 물질

7

반응물 4

HCID 674DimethylamineHCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 813036-Chloropyrazine-2-carbonitrile

생성물 1

HCID 232734596-(Dimethylamino)pyrazine-2-carbonitrile수율 55%

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

2-Chloro-6-cyanopyrazine (0.85 g, 6.09 mmol) and 1.67 N dimethylamine in acetonitrile (4.00 ml, 6.70 mmol) were added to THF (100 ml), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (0.50 g, 55%) as pale yellow crystals.

후처리

  1. washThe organic layer was washed with saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-aa45f43810d74b31af6b3328805d96d4
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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