Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → tert-Butyl [methyl(6-cyano-2-pyrazinyl)amino]acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 6-Chloropyrazine-2-carbonitrile | HCID 81303 | — |
| 반응물 | Sarcosine t-butyl ester hydrochloride | HCID 11252350 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | tert-Butyl [methyl(6-cyano-2-pyrazinyl)amino]acetate | HCID 70859746 | 27% |
반응 단계
2-Chloro-6-cyanopyrazine (2.09 g, 15.0 mmol), sarcosine tert-butyl ester hydrochloride salt (2.72 g, 15.0 mmol) and triethylamine (2.38 ml, 17.0 mmol) were added to DMF (30 ml), and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (1.00 g, 27%) as pale yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07767665B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-19e99a7d51ce44e6adc06719f872c43a |
| 출처 메모 | uspto-grants-2010_08 |