Water → 4-(Methylsulfanyl)pyridine-2-carbonitrile

HRID 499568노트

반응식

HRID 499568 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.[CH3:10][S-:11].[Na+].C(OCC)(=O)C.O>C1COCC1>[C:8]([C:4]1[CH:3]=[C:2]([S:11][CH3:10])[CH:7]=[CH:6][N:5]=1)#[N:9]

참가 물질

6

반응물 4

HCID 962WaterHCID 8857Ethyl AcetateHCID 6933424-Chloro-2-pyridinecarbonitrileHCID 4378561Sodium methanethiolate

생성물 1

HCID 203104474-(Methylsulfanyl)pyridine-2-carbonitrile수율 100.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

4-Chloro-2-cyanopyridine (2.18 g, 15.7 mmol) and sodium thiomethoxide (2.20 g, 31.4 mmol) were dissolved in THF (100 ml), and the mixture was refluxed for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (2.36 g, 99%) as pale yellow crystals.

후처리

  1. temperaturethe mixture was refluxed for 2 hrs
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-18dfba0e4c7c4f1aa9526e630f8c7848
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767665B2

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