Ammonia → 6-(4-Fluorophenyl)-1,2,4-triazin-3-amine

HRID 500106노트

반응식

HRID 500106 반응식
[NH3:1].Cl[C:3]1[N:4]=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[CH:7][N:8]=1>O1CCCC1>[F:15][C:12]1[CH:13]=[CH:14][C:9]([C:6]2[N:5]=[N:4][C:3]([NH2:1])=[N:8][CH:7]=2)=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 213152193-Chloro-6-(4-fluorophenyl)-1,2,4-triazine

생성물 1

HCID 672240676-(4-Fluorophenyl)-1,2,4-triazin-3-amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

Ammonia gas was bubbled through a solution of 3-chloro-6-(4-fluorophenyl)-1,2,4-triazine (600 mg, 0.0029 mol) in tetrahydrofuran (8 mL) for 5 min at −40° C. The reaction mixture was sealed and heated at 50° C. for 2 hours. The mixture was concentrated under reduced pressure to yield the desired product (550 mg) which was directly used in the next step without further purification. LCMS: (M+H)=209.1.

후처리

  1. customThe reaction mixture was sealed
  2. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-241f60c201cd4ffcb46cc022d1a70bcd
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07767675B2

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