3-Mercaptopropanol → 5-[2-[(3-hydroxypropyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one

HRID 50026

반응식

HRID 50026 반응식
[CH3:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6](=[O:7])[CH:5]=[C:4](/[CH:8]=[CH:9]/[C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[O:3]1.[SH:21][CH2:22][CH2:23][CH2:24][OH:25]>>[OH:25][CH2:24][CH2:23][CH2:22][S:21][CH:9]([C:10]1[CH:14]=[CH:13][S:12][CH:11]=1)[CH2:8][C:4]1[O:3][C:2]([CH3:1])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:6](=[O:7])[CH:5]=1

참가 물질

3

반응물 2

HCID 882113-MercaptopropanolHCID 11300541(E)-2-methyl-2-phenyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanone

생성물 1

HCID 101994355-[2-[(3-hydroxypropyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one

실험 절차

According to the procedure of Method A, Example 1, (E)-2-methyl-2-phenyl-5-[2-(3-thienyl)ethenyl]-3(2H)-furanone was reacted with 3-mercapto-1-propanol to provide 5-[2-[(3-hydroxypropyl)thio]-2-(3-thienyl)ethyl]-2-methyl-2-phenylfuran-3(2H)-one; 1H NMR (CDCl3) δ1.40 (br s, 1H), 1.65 and 1.68 (singlets, 3H), 1.68-1.82 (m, 2H), 2.42-2.57 (m, 2H), 3.10-3.27 (m, 2H), 3.67 (m, 2H), 4.42 (m, 1H), 5.37 and 5.39 (singlets, 1H), 7.05-7.18 (m, 2H), 7.27-7.40 (m, 6H); MS (HR-FAB) m/z 375.1113 (M+H calcd. for C20H23O3S2 375.1089).

출처 및 근거

ORD 기록
ord-3dcc60becf714af6bbd5177c23888703
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06710078B2

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